過去記事一覧
AASJホームページ > 2021年 > 7月 > 19日

7月19日 抗うつ剤としての幻覚剤 (8月18日号 Neuron 掲載予定論文)

2021年7月19日

重いうつ病に、様々な幻覚剤を用いる治療が急速に拡大している。臨床現場に最初に導入されたのは、麻酔剤ケタミンで、これまで何回も紹介してきた。麻酔剤ケタミンを幻覚剤と呼んでいいかどうか難しいところだが、ケタミンも解離体験を誘導することが知られている。

最近になって、幻覚を誘導するドラッグとして用いられていたキノコ、シビレタケに含まれているシロシビンが、セロトニン2A受容体の刺激を介して働き、抗うつ剤として働くことがわかって、FDAもFast Trackで2019年に認可している。最近発表されたThe New England Journal of Medicine(384,1402, 2021)では、抗うつ効果はセロトニン再吸収阻害剤と同等で、しかも副作用が少ない抗うつ剤として使えることが示された。

今日紹介するイエール大学からの論文はこのシロシビンの抗うつ効果の背景にある神経メカニズムを解明しようとした研究で8月18日号Neuronに掲載予定だ。タイトルは「Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo(シロシビンは前頭皮質の樹状突起スパインの迅速で長期間続く成長を誘導する)」だ。

研究は単純で、まずシロシビンがマウスにも幻覚を誘導する(頭を左右に振る動作を指標にしている)用量を決定した後、シロシビン投与後の内側前頭前皮質の樹状突起を長期間観察し、樹状突起スパインの成長を7日目と、34日目で記録している。

以前紹介したようにスパインの動態を長期間観察する方法(https://aasj.jp/news/watch/3680)が開発されたおかげといえる研究だが、投与直後にスパインの数がコントロールに比べて増加し、退縮自体は両群で変化がないため、結果シロシビンにより前頭葉のスパインの数が増えることがわかった。

脳全体で見てみると、前頭前皮質だけでなく、レベルは低いが辺縁系や運動野でも見られる。ヒスタミン2A受容体の阻害剤でこの効果が消えることから、ヒスタミン作動性の神経では同じ効果が得られるのではと結論している。また、効果はメスでより強く見られる。

シロシビン投与直後の神経活動をみると、興奮数と興奮の振幅が高まっており、神経興奮を介するシナプス増強が起こっていることを示している。

重要なことは、こうして誘導されたスパインの変化は、1ヶ月間も維持できることで、ケタミンと同じく一度の投与で迅速かつ長期間続く効果が得られることになる。

結果は以上で、樹状突起スパインの増加などはケタミンの場合と似ているが、作用標的がヒスタミン2A受容体と、うつ病に最も関わりのある神経伝達系なので、基礎的にその効果のメカニズムが明らかになることは、この治療を後押しするように思う。

カテゴリ:論文ウォッチ

Types of Board Management Software

2021年7月19日

Board management software is usually an application system used for managing the business of an company as well as its various departments. With many businesses now necessitating greater time management and productivity, aboard management software has become a vital need. Board management software helps to take care of staff plans, track bills and collaborate with other departments to improve proficiency and quality of work. This kind of also helps the organization to easily watch staff performance and recognize weaknesses which can be improving. The software program also helps in decision making and helps staff to understand directions and objectives evidently.

When setting up a new business it is important to form a great executive committee who will hire the mcafee vs webroot board management software. This mother board must establish specific goals for this company, such as the quantity of board get togethers every year, gross annual performance goals and quantitative and qualitative reviews. In this particular charter it will include types of procedures and credit reporting guidelines to get running the board meetings and how they will be executed. Then this kind of software may be used to create and track the meetings and ongoing conversations that are going on, allowing total communication between all parties for being reached. This board software can be contacted through a username and password system and supplies an modern overview of almost all board get togethers, minutes and decisions taken. It can also be custom-made to meet the specific needs of this company and it is members.

There are several board software options available, including desktop and online panels. Online plank meeting programs are easier to work with because everyone is able to log into the board assembly from anywhere, whereas it is more challenging to replace the knowledge in personal pc apps. There are many different types of board software, including the Ms Office Package apps. The board events in these apps are completely integrated with Word and Excel, and there is secure safe-keeping of private information and password cover of electronic mails. Many of the software come with the scheduling and planning tools, so that it is easy to routine future aboard meetings, daily activities and appointments on the go. Panel meetings can be employed as a way to speak with other panel members and share information on assignments and concerns.

カテゴリ:未分類

Anti-virus Software

2021年7月19日

Antivirus software, often referred to as anti-spyware, security, or perhaps antivirus software, is a computer system application meant to guard against, detect, and eliminate vicious software. There are various kinds of antivirus software program available. These include desktop applications, online applications, and other mass media players. A brand new antivirus course will usually have all these factors.

The anti-virus software shields computers from viruses which may have the ability to mount programs not having permission or perhaps remove programs https://www.appsguide.org/total-av-antivirus-review/ once they have been mounted. As well as protecting computers right from viruses, the application may be used to present computer network protection against attack by external users and malware which may also be placed on the system. It is also possible to get antivirus software that functions both responsibilities. This type of application may give comprehensive prevention of viruses and should not always be confused with firewalls. Firewalls serve several purpose.

Usually, antivirus application has been created to protect personal computers that connect to the Internet. In other words, it provides prevention of viruses that spread throughout the Internet and are transmitted over the network or lightweight storage equipment. Examples of these kind of viruses incorporate worms, phishing emails, and data or asset robbery programs. Antivirus protection is useful in preventing such infections, nonetheless it should also be applied to counter threats to computer systems and other priceless information stored about personal and business computers.

カテゴリ:未分類

The Best Antivirus Computer software For Windows XP

2021年7月19日

If you use Microsoft windows PCs, you need to have some kind of Microsoft Windows antivirus software inside your machine. You might have perhaps heard of all of the new “it” programs which can be out there — from infections, malware, malware, and scam to classical viruses and worms — and may even be infected with them. However you still desire a good anti-virus program attached to your PC, and also you need it to safeguard your personal information, your online activities, and your equipment itself coming from infections.

Although there’s no this kind of thing as being a completely free antivirus devoid of restrictions, these types of 5 no cost antivirus solutions offer a great collection of web protection features for Microsoft windows 7, Windows vista, and 15 PCs. And all of them are superior to the absolutely free Microsoft-recommended treatment, Microsoft Security Essentials (MS Essentials). For example , while the no cost version is going to scan your personal computer for malware and virus attacks, Microsoft company Security Essentials will carry out daily posts and comes with real-time prevention of spyware and malware. Additionally , you’ll be provided a web-based control panel, that may allow you to keep the machine fully updated and running because smoothly as it can be. And equally versions could have built-in protection against spyware, spyware and adware, and spyware and, so they can prevent any damaging intrusions by finding their way onto your machine.

Hence the bottom line is this: although there’s no these kinds of thing simply because the absolute best antivirus computer software for Windows XP, the top applications are still really worth purchasing pertaining to the excellent security they provide. And if you’re in XP at the moment, the no cost avira ant-virus for download should be enough to keep avgreview.com/how-to-choose-the-best-antivirus-software your system jogging efficiently – and to save some money. I know managed to tidy up my computer system using superior malware removing tools, and you can find out more about how I did it in the links underneath.

カテゴリ:未分類

Avira Software Blog page – Get to Know Your Computer Better

2021年7月19日

Avira software blog helps you become familiar with more with regards to your computer using its web-based user interface. It is also easy for you to manage all the files and folders that happen to be in your harddisk. The software is certainly used for the monitoring of the computer’s activities. That is, it may help you find out in the event that there are any kind of malicious programs or if your pc is afflicted with virtually any virus.

When you install this kind of software, you will be able to make use of the tools to scan your computer and let you know if the system seems to have any pathogen. This can be beneficial, especially if you are a one who loves to watch TV on a computer that is heavily infected with viruses. Additionally , Avira best antivirus will also help you clean up your personal computer so that your machine will work effortlessly again.

If you want using the internet but are afraid that your computer is actually slow to handle the technology and articles, then Avira will surely assist you. It also helps you find out how your personal computer is operating and your skill to improve it. In so many cases, these programs may be suggested by their makers because that they help users maximize their very own computer’s functionality and security features. Avira application blog will let you become more familiar with the different features which you can use in order to make your computer run like new.

カテゴリ:未分類

Aboard Room – Accessing Boardroom Technology

2021年7月19日

Board get togethers are a vital part of business and as the owner/chairman of a company, you’ll certainly be required to enroll in board conferences from time for you to change and keep this company moving forward. Often times, the plank meetings might be conducted in various countries, with regards to the type of organization. For example , you might have meetings in Japan, Canada or the United states of america. Regardless of where you are finally located, there are several key things that are predicted at your panel meetings. The initial item is formal outfits, which is a must.

In addition to formally attired boardroom attire, you should also have on the right technology equipment to assist you clearly connect to members for the boardroom. Generally speaking, all subscribers of the boardroom must have a connection to the internet, including crystal clear hearing and sight capacities. This allows you and your directors the ability to listen to questions and comments from other members belonging to the boardroom and from others who could possibly be attending the meeting. In today’s highly wired and complex society, having these technical capabilities helps to ensure that everyone https://managingworkflow.org/2019/11/09/workflow-management-rules-and-tools/ understands the proceedings for the boardroom.

An additional item that you should consider in board meetings has the right technology in place to help you conduct the meetings. For instance , many businesses use videoconferencing and audio meeting capabilities to facilitate get togethers, including board events. By using videoconferencing or audio conference functions, you can carry out meetings around the globe, even when you are traveling abroad. Additionally , the video conferencing and audio discussion capabilities let you conduct events that involve multiple people in several locations and let for current interactions among people. Having the right technology in place will ensure that your board group meetings run effortlessly.

カテゴリ:未分類
2021年7月
 1234
567891011
12131415161718
19202122232425
262728293031